The significantly-updated-for-2008 Honda Odyssey minivan receives new exterior styling along with a more fuel-efficient version of the available Variable Cylinder Management (VCM) i-VTEC V-6 engine. The Odyssey strengthens its styling and functional advantages while adding even more premium features.

Odyssey LX and EX models are equipped with 3.5-liter, all-aluminum, SOHC VTEC engine that produces 244 horsepower at 5750 rpm and 240 lb-ft. of torque at 5000 rpm. The Odyssey EX-L and Touring models feature a 3.5-liter, all-aluminum, SOHC i-VTEC V-6 engine with VCM for enhanced fuel efficiency. This engine generates 241 hp at 5700 rpm and 242 lb-ft. of torque at 4900 rpm.

Exterior styling focuses on a bolder, six-sided grille design and a front bumper fascia with crisp lines that add to the vehicle's dynamic and premium appearance. Interior styling receives updates in the form of new colors and textures for the instrument panel, along with premium fabric for Odyssey LX and EX seating surfaces. Further interior refinements include an additional storage bin in the second row plus one seat (standard on Odyssey EX, EX-L, and Touring), standard MP3/Windows Media Audio (WMA) compatibility (CD-based), and a standard auxiliary input jack.

All Odyssey models are equipped with vehicle stability assist (VSA) also known as electronic stability control, and standard anti-lock brakes with brake assist, advanced dual-stage, dual-threshold driver and front passenger SRS airbags, front side airbags with passenger-side Occupant Protection Detection System (OPDS), three-row side-curtain airbags with a rollover sensor, and a pedestrian safety design in the front of the vehicle. An Advanced Compatibility Engineering (ACE) body structure provides enhanced occupant protection in case of a frontal collision. New for 2008, active front seat head restraints and daytime running lights have been added.